Publications


Original Articles


Publications in Google Scholar

[41]  Sensini A, Raimondi L, Malerba A, Silva CP, Zucchelli A, Tits A, Ruffoni D, Blouin S, Hartmann MA, van Griensven M, Moroni L. Understanding the structure and mechanics of the sheep calcaneal enthesis: a relevant animal model to design scaffolds for tissue engineering applications. Biomaterals Advances 2025. [PDF]

[40]  A. Tits, S. Blouin, M. Rummler, J.F. Kaux, P. Drion, G. Harry van Lenthe, R. Weinkamer, M.A. Hartmann, D. Ruffoni, Structural and functional heterogeneity of mineralized fibrocartilage at the Achilles tendon-bone insertion. Acta Biomaterialia 2023. [PDF]

[39]  A.J. Lew, C.A. Stifler, A. Cantamessa, A. Tits, D. Ruffoni, Pupa U. P. A. Gilbert, M.J. Buehler, Deep learning virtual indenter maps nanoscale hardness rapidly and non-destructively, revealing mechanism and enhancing bioinspired design. Matter 6 2023; 1-17. [PDF]

[38]  A.J. Lew, C.A. Stifler, A. Tits, C.A. Schmidt, A. Scholl, A. Cantamessa, L. Müller, Y. Delaunois, P.  Compère, D. Ruffoni, M.J. Buehler*, Pupa U. P. A. Gilbert*, A Molecular-Scale Understanding of Misorientation Toughening in Corals and Seashell. Advanced Materials 2023; 10.1002/adma.202300373. [PDF]

*Equal supervision

[37]  Y. Delaunois, A. Tits, Q. Grossman, S. Smeets, C. Malherbe, G. Eppe, G. Harry van Lenthe, D. Ruffoni*, P. Compère*, Design strategies of the mantis shrimp spike: How the crustacean cuticle became a remarkable biological harpoon. Natural Sciences 2023; e20220060. [PDF]

*Equal supervision

[36] M. Gattin, N. BochudG. RosiQ. GrossmanD. Ruffoni, S. Naili, Ultrasonic bandgaps in viscoelastic 1D-periodic media: Mechanical modeling and experimental validation. Ultrasonics 131 2023; 106951. [PDF]

[35] M. Gattin, N. BochudG. RosiQ. GrossmanD. Ruffoni, S. Naili, Ultrasound characterization of the viscoelastic properties of additivley manufactured photopolymer materials. The Journal of the Acoustical Society of America 152 2022; 10.1121/10.0014180. [PDF]

[34] T. Habets, F. Siragusa, A.J. Müller, Q. Grossman, D. Ruffoni, B. Grignard, C. DetrembleurFacile construction of functional poly(monothiocarbonate) copolymers under mild operating conditions. Polymer Chemistry 2022, 13, 3076-3090. [PDF]

[33] A. Aghaei, N. BochudG. RosiQ. GrossmanD. Ruffoni, S. Naili, Ultrasound characterization of bioinspired functionally graded soft-to-hard composites: Experiment and modeling. The Journal of the Acoustical Society of America 151 2022; 10.1121/10.0009630. [PDF]

[32] L. De Noni, L. Zorzetto, F. Briatico-Vangosa, M. Rink, D. Ruffoni, L. Andena, Modelling the interphase of 3D printed photo-cured polymers. Composites Part B: Engineering 2022; 109737. [PDF]

[31] Y. Delaunois, S. Smeets, C. Malherbe, G. Eppe, D. Lecchini, D. Ruffoni, P. Compère. Structure and mineralization of the spearing mantis shrimp (Stomatopoda; Lysiosquillina maculata) body and spike cuticles. Journal of Structural Biology 2021; 107810. [PDF

[30] A. Tits, E. Plougonven, S. Blouin, M. A. Hartmann, J-F Kaux, P. Drion, J. Fernandez, G.H. van Lenthe, D. Ruffoni. Local anisotropy in mineralized fibrocartilage and subchondral bone beneath the tendon-bone interface. Scientific Reports 2021; 11:16534. [PDF]

[29] A. Tits and D. Ruffoni. Joining soft tissues to bone: insights from modeling and simulations. Bone Reports 2021; 100742. [PDF]

[28] L. Zorzetto, L. Andena, F. Briatico Vangosa, L. De Noni, J-M Thomassin, C. Jérôme, Q. Grossman, A. Mertens, R. Weinkamer, M. Rink, D. Ruffoni. Properties and role of interfaces in multimaterial 3D printed composites. Scientific Reports 2020; 22285. [PDF]

[27] M.J. Mirzaali, A Herranz de la Nava, D. Gunashekar, M. Nouri-Goushki, R.P.E. Veeger, Q. Grossman, L. Angeloni, M.K. Ghatkesar, L.E. Fratila-Apachitei, D. Ruffoni, E.L. Doubrovski, A.A. ZadpoorMechanics of bioinspired functionally graded soft-hard composites made by multi-material 3D printing. Composite Structures 2020; 111867. [PDF]

[26] Z. Li, D. Betts, G. Kuhn, M. Schirmer, R. Müller and D. Ruffoni. Mechanical regulation of bone formation and resorption around implants in a mouse model of osteopenic bone. Journal of the Royal Society Interface 2019; 16:20180667. [PDF]

[25] L. Zorzetto and D. Ruffoni. Wood-Inspired 3D-Printed Helical Composites with Tunable and Enhanced Mechanical Performance. Advanced Functional Materials 2019; 29, 1805888 (1-9). [PDF]

[24] Z. Li, R. Müller and D. Ruffoni. Bone Remodeling and Mechanobiology Around Implants: Insights From Small Animal Imaging. Journal of Orthopaedic Research 2018; 36(2):584-593. [PDF]

[23] Z. Li, G. Kuhn, M. Schirmer, R. Müller and D. Ruffoni. Impaired bone formation in ovariectomized mice reduces implant integration as indicated by longitudinal in vivo micro-computed tomography. PLoS ONE 12(9): e0184835. [PDF]

[22] L. Zorzetto and D. Ruffoni. Re-entrant inclusions in cellular solids: from defects to reinforcements. Composite Structures 2017; 176: 195–204. [PDF]

[21] Z. Li, G. Kuhn, M. von Salis-Soglio, S.J. Cooke, M. Schirmer, R. Müller and D. Ruffoni. In vivo monitoring of bone architecture and remodeling after implant insertion: the different responses of cortical and trabecular bone. Bone 2015; 81: 468–477. [PDF]

[20] M.M. Maurer, R. Weinkamer, Ralph Müller and D. Ruffoni. Does mechanical stimulation really protect the architecture of trabecular bone? A simulation study. Biomechanics and Modeling in Mechanobiology 2015,14:795–805. [PDF]

[19] A. Zwahlen, D. Christen, D. Ruffoni, P. Schneider, W. Schmölz and R. Müller. Inverse Finite Element Modeling for Characterization of Local Elastic Properties in Image-Guided Failure Assessment of Human Trabecular Bone . Journal of Biomechanical Engineering 2015; 137:011012-1. [PDF]

[18] L. Bounoure, D. Ruffoni, R. Müller, G. Kuhn, S. Bourgeois, O. Devuyst and C.A. Wagner. The Role of the Renal Ammonia Transporter Rhcg in Metabolic Responses to Dietary Protein . Journal of the American Society of Nephrology 2014; 25:2040-2052. [PDF]

[17] F. Donaldson, D. Ruffoni, P. Schneider, A. Levchuk, P. Pankaj and R. Müller. Modeling microdamage behavior of cortical bone. Biomechanics and Modeling in Mechanobiology 2014; 13:1227-1242. [PDF]

[16] Zermatten, J. Vetsch, D. Ruffoni, S. Hofmann, R. Müller and A. Steinfeld. Micro-computed tomography based modeling of shear stresses in regular and irregular scaffolds in a perfusion bioreactor. Annals of Biomedical Engineering 2014; 42:1085-1094. [PDF]

[15] H.W. Lau, D.J. Baylink, X.D. Zhou, D. Rodriguez, L.F. Bonewald, Z. Li, D. Ruffoni, R. Müller, C. Kesavan and M.H.C. Sheng. Osteocyte-derived insulin-like growth factor-1 is essential for determining bone mechanosensitivityAmerican Journal of Physiology – Endocrinology and Metabolism 2013; 305:E271-E281. [PDF]

[14] C. Lukas, D. Ruffoni, F. M. Lambers, F. A. Schulte, G. Kuhn, P. Kollmannsberger, R. Weinkamer and R. Müller. The mineralization kinetics in trabecular bone quantified by in vivo micro-computed tomography in a mouse model. Bone 2013; 56: 55–60. [PDF]

[13] F. Schulte, D. Ruffoni, F. M. Lambers, G. Kuhn, D. Christen, D. J. Webster and R. Müller. Local Mechanical Stimuli Regulate Bone Formation and Resorption in Mice at the Tissue Level. Plos One 2013; 8: e62172. [PDF]

[12] F. Lambers, K. Koch, G. Kuhn, D. Ruffoni, C. Weigt, F.A. Schulte and R. Müller. Trabecular bone adapts to long-term cyclic loading by increasing stiffness and normalization of dynamic morphometric rates. Bone 2013; 55: 325–334. [PDF]

[11] D. Ruffoni, T. Kohler, R. Voide, A.J. Wirth, L.R. Donahue, R. Müller and G.H. van Lenthe. High – throughput quantification of the mechanical competence of murine femora — A highly automated approach for large-scale genetic studies. Bone 2013; 55: 216–221. [PDF]

[10] F. Schulte, A. Zwahlen, F. M. Lambers, G. Kuhn, D. Ruffoni, D. Betts, D. J. Webster and R. Müller. Strain-adaptive in silico modeling of bone adaptation – a computer simulation validated by in vivo micro-computed tomography data. Bone 2013, 52: 485-492. [PDF]

[9] D. Ruffoni, A. J. Wirth, J. A. Steiner, I. A. Parkinson, R. Müller and G. H. van Lenthe. The different contributions of cortical and trabecular bone to implant anchorage in a human vertebra. Bone 2012; 50:733-738. [PDF]

[8] G. Zickler, D. Ruffoni, J. W. C. Dunlop, R. Elbaum, R. Weinkamer, P. Fratzl and T. Antretter. Finite element modeling of the cyclic wetting mechanism in the active part of wheat awns. Biointerphases 2012; 7:E1-E9. [PDF]

[7] D. Ruffoni, R. Müller and G. H. van Lenthe. Mechanisms of reduced implant stability in osteoporotic bone. Biomechanics and Modeling in Mechanobiology 2012; 11:313–323. [PDF]

[6] C. Lukas, P. Kollmannsberger, D. Ruffoni, P. Roschger, P. Fratzl and R. Weinkamer. The Heterogeneous Mineral Content of Bone—Using Stochastic Arguments and Simulations to Overcome Experimental Limitations. Journal of Statistical Physics 2011; 144:316–331. [PDF]

[5] D. Ruffoni, J. W. C. Dunlop, P. Fratzl and R. Weinkamer. Effect of minimal defects in periodic cellular solids. Philosophical Magazine 2010; 90:1807–1818. [PDF]

[4] I. Kallai, G. H. van Lenthe, D. Ruffoni, Y. Zilberman, R. Müller, G. Pelled and D. Gazit. Quantitative, structural and image-based mechanical analysis of nonunion fracture repaired by genetically engineered mesenchymal stem cells. Journal of Biomechanics 2010; 43:2315–2320. [PDF]

[3] D. Ruffoni, P. Fratzl, P. Roschger, K. Klaushofer and R. Weinkamer. Effect of temporal changes in bone turnover on the bone mineralization density distribution: a computer simulation study. Journal of Bone and Mineral Research 2008; 23:1905-1914. [PDF]

[2] M. Soncini, S. Vesentini, D. Ruffoni, M. Orsi, M. Deriu and A. Redaelli. Mechanical response and conformational changes of alpha-actinin domains during unfolding: a molecular dynamics study. Biomechanics and Modeling in Mechanobiology 2007; 6:399-407. [PDF]

[1] D. Ruffoni, P. Fratzl, P. Roschger, K. Klaushofer and R. Weinkamer. The bone mineralization density distribution as a fingerprint of the mineralization process. Bone 2007; 40:1308-19. [PDF]

updated on 4/22/25

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