Marie Curie ReBone
Project description
The musculoskeletal system is highly susceptible to aging and trauma, leading to clinical conditions that place a significant strain on healthcare systems. For patients needing bone-substitute implants to treat critical-size bone defects, there is an urgent need for personalized solutions that improve clinical outcomes, materials with enhanced mechanical reliability without compromising bioactivity and bioresorbability, and optimized manufacturing technologies for high-quality, reliable products.
To address these needs, the Horizon Europe Marie Skłodowska-Curie programme (MSCA-DN) has funded the Doctoral Network ReBone, which brings the cooperation among the following partners: Politecnico di Milano (Italy), Politecnico di Torino (Italy), Università del Piemonte Orientale (Italy), Lithoz GmbH (Austria), Ludwig Boltzmann Institute (Austria), University of Salzburg (Austria), University of Belgrade (Republic of Serbia), MEDAPP SPÓŁKA AKCYJNA (Poland).
The consortium aims to train the next generation of researchers in developing personalized bone-substitute implants based on bioactive ceramics, addressing the health and societal burdens of trauma and bone diseases. To achieve its overarching aim ReBone will develop cutting-edge in-silico models based on advanced computational methods and advanced characterization and validation techniques for achieving personalized implants with the following characteristics:
· Tailored and reliable mechanical and physical properties;
· Optimal osteo-integration capabilities;
· Mechanical, physical and mechano-biological target functions with patient-specific constraints, that take into account the load-bearing anatomical location, the biomechanical stress and the quality of the tissue at the implantation sites, identified from selected clinical data.
